Quantitating Glomerular Endothelial Fenestration: An Unbiased Stereological Approach
نویسندگان
چکیده
منابع مشابه
Quantitating glomerular endothelial fenestration: an unbiased stereological approach.
BACKGROUND/AIMS Glomerular endothelial cells are fenestrated, allowing for especially high transcellular hydraulic conductivity. Current knowledge about endothelial fenestration structural changes in disease conditions is limited, partly due to the absence of robust methodologies to quantitate these structures. Herein, we propose a novel method for estimating the percentage of endothelial fenes...
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Podocyte detachment and reduced endothelial cell fenestration and relationships between these features and the classic structural changes of diabetic nephropathy have not been described in patients with type 2 diabetes. Here we studied these relationships in 37 Pima Indians with type 2 diabetes of whom 11 had normal albuminuria, 16 had microalbuminuria, and 10 had macroalbuminuria. Biopsies fro...
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Glomerular endothelial cell (GEnC) fenestrations are analogous to podocyte filtration slits, but their important contribution to the glomerular filtration barrier has not received corresponding attention. GEnC fenestrations are transcytoplasmic holes, specialized for their unique role as a prerequisite for filtration across the glomerular capillary wall. Glomerular filtration rate is dependent ...
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ژورنال
عنوان ژورنال: American Journal of Nephrology
سال: 2011
ISSN: 1421-9670,0250-8095
DOI: 10.1159/000327075